Catalytic direct asymmetric Michael reactions: Addition of unmodified ketone and aldehyde donors to alkylidene malonates and nitro olefins

被引：192

作者：

Betancort, JM

Sakthivel, K

Thayumanavan, R

Tanaka, F

Barbas, CF

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA

来源：

SYNTHESIS-STUTTGART | 2004年 / 09期

关键词：

asymmetric catalysis; Michael additions; organocatalysis; ketones; enamines;

D O I：

10.1055/s-2004-822392

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Michael additions of a number of ketones and aldehydes to alkylidene malonates and nitro olefins were studied. The reactions employ small organic molecules as catalyst under mild reaction conditions and do not require preactivation of the carbonyl donors. These reactions afforded a variety of highly functionalized products in good yields with moderate to good enantioselectivity.

引用

收藏

页码：1509 / 1521

页数：13

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