Resistance to fluoroquinolones in Salmonella:: emerging mechanisms and resistance prevention strategies

被引：88

作者：

Giraud, Etienne

Baucheron, Sylvie

Cloeckaert, Axel

机构：

[1] ENVN Chimiotherapie Aquacole & Environm, INRA, UMR, F-44307 Nantes, France

[2] INRA, Ctr Rech Tours, Unit Bioagresseurs Sante Environm, F-37380 Nouzilly, France

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 07期

关键词：

fluoroquinolones; resistance; Salmonella;

D O I：

10.1016/j.micinf.2005.12.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We review the current state of knowledge about the genetic and biochemical mechanisms that mediate quinolone resistance in Salmonella. They include modifications of topoisomerase targets, increased efflux activity and the recently described topoisomerase protection by the plasmid-encoded Qnr protein. We discuss what factors may determine the order of implementation of these various mechanisms in a particular strain, and what strategies could be used to combat resistance, from the inhibition of mutagenesis mechanisms to counteracting, during fluoroquinolone treatment, of resistance mechanisms already set in the infecting strain. (c) 2006 Elsevier SAS. All rights reserved.

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页码：1937 / 1944

页数：8

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