Mechanisms of Regulation of the Chemokine-Receptor Network

被引：246

作者：

Stone, Martin J. ^{[1
,2
]}

Hayward, Jenni A. ^{[1
,2
]}

Huang, Cheng ^{[1
,2
]}

Huma, Zil E. ^{[1
,2
]}

Sanchez, Julie ^{[1
,2
]}

机构：

[1] Monash Univ, Monash Biomed Discovery Inst, Infect & Immun Program, Clayton, Vic 3800, Australia

[2] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

chemokine; chemokine receptor; regulation; binding; expression; glycosaminoglycan; post-translational modification; oligomerization; signaling; inhibitor; PROTEIN-COUPLED RECEPTOR; SARCOMA-ASSOCIATED HERPESVIRUS; GTPASE-ACTIVATING PROTEINS; BETA-ARRESTIN RECRUITMENT; HUMAN BREAST-CANCER; N-TERMINAL REGION; ACTIVITY IN-VITRO; CC-CHEMOKINE; CHEMOATTRACTANT PROTEIN-1; TYROSINE SULFATION;

D O I：

10.3390/ijms18020342

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competitive binding interactions; genetic polymorphisms; mRNA splice variation; variation of expression, degradation and localization; down-regulation by atypical (decoy) receptors; interactions with cell-surface glycosaminoglycans; post-translational modifications; oligomerization; alternative signaling responses; and binding to natural or pharmacological inhibitors.

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页数：33

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