Two cases of Merkel cell tumour arising in patients with chronic lymphocytic leukemia

被引：58

作者：

Ziprin, P ^{[1
]}

Smith, S ^{[1
]}

Salerno, G ^{[1
]}

Rosin, RD ^{[1
]}

机构：

[1] St Marys Hosp, Dept Surg, London W2 1NY, England

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2000年 / 142卷 / 03期

关键词：

chronic lymphocytic leukemia; Merkel cell tumour;

D O I：

10.1046/j.1365-2133.2000.03370.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Chronic lymphocytic leulkaemia (CLL) has been associated with an increased incidence of second neoplasms. especially skin cancers such as basal and squamous cell carcinomas. No association with the rarer skin cancer, the Merkel cell tumour (MCT), has previously been reported. Two patients with MCT had a previous diagnosis of CLL. MCT is an aggressive skin cancer, as up to 45% of patients have lymph node involvement at presentation and 5-year disease-free survival is as low as 30%. It is most commonly found on sun-exposed areas of the body, and ultraviolet radiation together with drug-induced or CLL-induced immunosuppression may be the underlying mechanism in the observed relationship between CLL and other skin cancers.

引用

页码：525 / 528

页数：4

共 22 条

[1] EVIDENCE OF AN ASSOCIATION BETWEEN NON-HODGKINS-LYMPHOMA AND SKIN-CANCER [J].