Differential regulation of neurotrophin expression by mitogens and neurotransmitters in mouse lymphocytes

被引：69

作者：

Barouch, R

Appel, E

Kazimirsky, G

Braun, A

Renz, H

Brodie, C ^{[1
]}

机构：

[1] Bar Ilan Univ, Fac Life Sci, IL-52900 Ramat Gan, Israel

[2] Humboldt Univ, Dept Clin Chem & Biochem, Charite Virchow Clin, Berlin, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 103卷 / 02期

关键词：

neurotrophins; mitogens; neurotransmitters; lymphocytes; immune system;

D O I：

10.1016/S0165-5728(99)00233-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study. we examined the expression of neurotrophins in mouse lymphocytes and the regulation of their expression by mitogens and neurotransmitters. We found that mixed splenocytes as well as T and B lymphocytes expressed mRNA for all the neurotrophins examined. Differential regulation of the neurotrophins was obtained upon stimulation of the cells. Thus. LPS increased the expression of NGF, BDNF and NT-3 in splenocytes and B cells. whereas Con-A increased the mRNA of NT-3 and NT-4 in T cells and NGF expression in splenocytes. The neurotransmitter substance P and the beta-adrenergic agonist, isoproterenol induced an increase in the expression of NGF. Our results suggest an important role for the different neurotrophins in the function of the immune system and point to a bi-directional interaction between neurotrophins and neurotransmitters in this system. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

引用

页码：112 / 121

页数：10

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