Differential functions of lateral and medial rostral prefrontal cortex (area 10) revealed by brain-behavior associations

被引：94

作者：

Gilbert, Sam J.

Spengler, Stephanie

Simons, Jon S.

Frith, Christopher D.

Burgess, Paul W.

机构：

[1] UCL, Inst Cognit Neurosci, London WC1N 3AR, England

[2] UCL, Dept Psychol, London WC1N 3AR, England

[3] UCL, Wellcome Dept Imaging Neurosci, Inst Neurol, London WC1N 3AR, England

来源：

CEREBRAL CORTEX | 2006年 / 16卷 / 12期

基金：

英国惠康基金;

关键词：

Brodmann's area 10; fMRI; frontal pole; meta-analysis; PET; response time;

D O I：

10.1093/cercor/bhj113

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We analyzed the behavioral data from 104 neuroimaging studies using positron. emission tomography or functional magnetic resonance imaging that reported activation peaks in rostral prefrontal Cortex (PFC), approximating Brodmann's area 10. The distribution of absolute x coordinates of activation peaks (i.e., x coordinate regardless of hemisphere) differed significantly from a unimodal normal distribution, reflecting distinct clusters of activation in lateral and medial subregions. These 2 clusters were associated with different patterns of behavioral data. Lateral activations were associated with contrasts between experimental and control conditions where response times (RTs) were slower in the experimental condition. Medial activations were associated with contrasts where RTs were, if anything, faster in experimental than control conditions. These findings place important constraints on theories of rostral PFC functions.

引用

页码：1783 / 1789

页数：7

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