Human plasma cells express granzyme B

被引：33

作者：

Xu, Wei ^{[1
,2
]}

Narayanan, Priya ^{[1
]}

Kang, Ning ^{[1
]}

Clayton, Sandra ^{[1
]}

Ohne, Yoichiro ^{[1
]}

Shi, Peiqing ^{[1
]}

Herve, Marie-Cecile ^{[1
]}

Balderas, Robert ^{[3
]}

Picard, Capucine ^{[4
,5
]}

Casanova, Jean-Laurent ^{[6
]}

Gorvel, Jean-Pierre ^{[7
,8
,9
]}

Oh, Sangkon ^{[1
]}

Pascual, Virginia ^{[1
]}

Banchereau, Jacques ^{[1
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX USA

[2] Roche Glycart, Pharma Res & Early Dev, CH-8952 Schlieren, Switzerland

[3] BD Biosci, San Diego, CA USA

[4] Paris Descartes Univ, Necker Med Sch, INSERM, Lab Human Genet Infect Dis,Necker Div,U980, Paris, France

[5] Hop Necker Enfants Malad, AP HP, Study Ctr Primary Immunodeficiencies, Paris, France

[6] Rockefeller Univ, St Giles Lab Human Genet Infect Dis, New York, NY 10021 USA

[7] Aix Marseille Univ, UM2 Marseille, CIML, Marseille, France

[8] INSERM, U1104, F-13258 Marseille, France

[9] CNRS, UMR7280, Marseille, France

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2014年 / 44卷 / 01期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; DENDRITIC CELLS; LYMPH-NODE; T-CELLS; RHEUMATOID-ARTHRITIS; SUBCAPSULAR SINUS; GERMINAL-CENTERS; DIFFERENTIATION; ANTIGEN; IL-21;

D O I：

10.1002/eji.201343711

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

While studying the plasma cell (PC) compartment in human tonsils, we identified that immunoglobulin kappa or lambda chain-expressing PCs are the main cells expressing granzyme B (GrzB). In vitro studies revealed that activated B cells differentiated into GrzB-expressing PCs when co-cultured with macrophages and follicular helper T cells. This effect could be reproduced on combined stimulation of IL-15 (produced by macrophages) and IL-21 (produced by T follicular helper cells) in a STAT3-dependent manner. Whereas IL-21 triggers the transcription of mRNA of GrzB, IL-15 synergizes the translation of GrzB proteins. The precise role of GrzB in PC biology remains to be understood and studies in mice will not help as their PCs do not express GrzB. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：275 / 284

页数：10

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