Facile fabrication of gradient bioactive coating with hierarchically porous structures and superior cell response

被引：7

作者：

Huang, Di ^{[1
,2
]}

Xi, Shaohui ^{[1
]}

Zuo, Yi ^{[2
]}

Wei, Yan ^{[1
]}

Guo, Meiqing ^{[1
]}

Wang, Hefeng ^{[1
]}

Chen, Weiyi ^{[1
,3
]}

Li, Yubao ^{[2
]}

机构：

[1] Taiyuan Univ Technol, Coll Mech, Shanxi Key Lab Mat Strength & Struct Impact, Taiyuan 030024, Peoples R China

[2] Sichuan Univ, Analyt & Testing Ctr, Res Ctr Nanobiomat, Chengdu 610064, Peoples R China

[3] Taiyuan Univ Technol, Inst Appl Mech & Biomed Engn, Taiyuan 030024, Peoples R China

来源：

MATERIALS LETTERS | 2014年 / 133卷

关键词：

Biomaterials; Microstructure; Hierarchical; Gradient; Cytocompatibility; CALCIUM-PHOSPHATE SCAFFOLDS; CRITICAL-SIZE DEFECTS; MECHANICAL-PROPERTIES; MULTISCALE POROSITY; BONE; OSTEOINTEGRATION; HYDROXYAPATITE; REGENERATION; REPAIR;

D O I：

10.1016/j.matlet.2014.06.168

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

To better construct the interface between implant and natural bone, novel gradient nano-hydroxyapatite/polyamide (nHA/PA) composite coating with hierarchically porous structures was prepared using phase-inversion technique and particle-leaching processing. Scanning electron microscopy observation shows that the size of macropores on the surface ranges from 300 to 500 mu m. There are abundant micron/submicron-scale pores distributed on the walls of the macropores. Energy-dispersive X-ray spectroscopy analysis indicates that nHA component increases gradually at the interface from the porous transition region to nHA-rich coating layer and then keeps stable towards the coating surface. The osteoblast-like cells (MG63) were cultured on the samples. The results confirm that the samples with nHA-rich coatings and hierarchical structures are favorable to the attachment and proliferation of MG63 cells, and they are potentially attractive candidates for bone repair applications. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：105 / 108

页数：4

共 16 条

[1]

Mechanical properties and reliability of glass-ceramic foam scaffolds for bone repair [J].