SMN-mediated assembly of RNPs: a complex story

被引：200

作者：

Meister, G ^{[1
]}

Eggert, C ^{[1
]}

Fischer, U ^{[1
]}

机构：

[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0962-8924(02)02371-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although many RNA-protein complexes or ribonucleoproteins (RNPs) assemble spontaneously in vitro, little is known about how they form in the environment of a living cell. Insight into RNP assembly has come unexpectedly from functional analyses of the survival motor neuron (SMN) protein, a gene product that is affected in the neuromuscular disease spinal muscular atrophy. These studies show that the assembly of spliceosomal U-rich small nuclear RNPs in vivo depends on the activity of two large protein complexes, one of which contains the SMN protein. These complexes might also facilitate the assembly of other cellular RNPs.

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页码：472 / 478

页数：7

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