Mechanism of transcriptional activation by the Myc oncoproteins

被引：146

作者：

Cowling, Victoria H.

Cole, Michael D.

机构：

[1] Dartmouth Med Sch, Dept Pharmacol, Lebanon, NH 03756 USA

[2] Dartmouth Med Sch, Dept Genet, Lebanon, NH 03756 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2006年 / 16卷 / 04期

基金：

英国医学研究理事会;

关键词：

Myc; transcription; chromatin; acetyltransferase; polymerase; proliferation; oncogenesis; cancer; cofactor;

D O I：

10.1016/j.semcancer.2006.08.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The Myc family proteins are potent oncogenes that can activate and repress a very large number of cellular target genes. The amino terminus of Myc contains a transactivation domain that can recruit a number of nuclear cofactors with diverse activities. Functional studies link transactivation to the ability of Myc to promote normal cell proliferation and for oncogenic transformation. The biochemical mechanism of Myc-mediated transactivation has revealed a wide range of effects on chromatin and basal transcription. This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：242 / 252

页数：11

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