Preventing thromboembolic complications in cancer patients after surgery: a role for prolonged thromboprophylaxis

被引：68

作者：

Rasmussen, MS ^{[1
]}

机构：

[1] Bispebjerg Hosp, Dept Surg Gastroenterol, DK-2400 Copenhagen NV, Denmark

来源：

CANCER TREATMENT REVIEWS | 2002年 / 28卷 / 03期

关键词：

major abdominal surgery; cancer; DVT; LMWH;

D O I：

10.1016/S0305-7372(02)00043-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients undergoing major abdominal surgery for malignancy are at particularly high risk of developing VTE. Extra protection against this can be given to patients with cancer by using a higher dose of LMWH than normally used for prophylaxis, with no increase in bleeding complications. Despite thromboprophylaxis with high-dose LMWH for the first postoperative week, the rate of late VTE is estimated to be between 10% and 20%. A meta-analysis of two studies using dalteparin or enoxaparin has shown that prolonging thromboprophylaxis for a further 3 weeks significantly reduces the risk of late occurring VTE by 62%, Thrombolprophylaxis with LMWH for at least one month should be considered in patients undergoing surgery for malignant disease. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：141 / 144

页数：4

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