Synthesis of shell cross-linked micelles at high solids in aqueous media

被引：146

作者：

Bütün, V

Wang, XS

Báñez, MVD

Robinson, KL

Billingham, NC

Armes, SP ^{[1
]}

Tuzar, Z

机构：

[1] Univ Sussex, Sch Chem Phys & Environm Sci, Brighton BN1 9QJ, E Sussex, England

[2] Acad Sci Czech Republ, Inst Macromol Chem, CR-16206 Prague 6, Czech Republic

来源：

MACROMOLECULES | 2000年 / 33卷 / 01期

关键词：

D O I：

10.1021/ma9914669

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The synthesis of well-defined shell cross-linked knedel (SCK) micelles in relatively concentrated solution is described. This was achieved in an aqueous media using a polyethylene oxide-block-2-(dimethylamino)ethyl methacrylate (PEO-DMA-MEMA) triblock copolymer. H NMR spectrum indicated average degrees of polymerization for the DMA and MEMA blocks of 57 and 62, respectively. GPC of the sample indicated a polydispersity of 1.33. Results verify that sterically stabilized SCK micelles with tunable core hydrophilicity can be readily prepared at high solids in aqueous media using ABC triblock copolymers.

引用

页码：1 / 3

页数：3

共 19 条

[1] Synthesis of shell cross-linked micelles with tunable hydrophilic/hydrophobic cores
Bütün, V
Billingham, NC
Armes, SP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (46) : 12135 - 12136
[2] Biodegradable polymeric microparticles for drug delivery and vaccine formulation: the surface attachment of hydrophilic species using the concept of poly(ethylene glycol) anchoring segments
Coombes, AGA
Tasker, S
Lindblad, M
Holmgren, J
Hoste, K
Toncheva, V
Schacht, E
Davies, MC
Illum, L
Davis, SS
[J]. BIOMATERIALS, 1997, 18 (17) : 1153 - 1161
[3] Polystyrene block poly(2-cinnamoylethyl methacrylate) nanospheres with cross-linked shells
Ding, JF
Liu, GJ
[J]. MACROMOLECULES, 1998, 31 (19) : 6554 - 6558
[4] Hairy, semi-shaved, and fully shaved hollow nanospheres from polyisoprene block poly(2-cinnamoylethyl methacrylate)
Ding, JF
Liu, GJ
[J]. CHEMISTRY OF MATERIALS, 1998, 10 (02) : 537 - 542
[5] Water-soluble hollow nanospheres as potential drug carriers
Ding, JF
Liu, GJ
[J]. JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (31) : 6107 - 6113
[6] Nanocages derived from shell cross-linked micelle templates
Huang, HY
Remsen, EE
Kowalewski, T
Wooley, KL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (15) : 3805 - 3806
[7] Hydrogel-coated glassy nanospheres: A novel method for the synthesis of shell cross-linked knedels
Huang, HY
Kowalewski, T
Remsen, EE
Gertzmann, R
Wooley, KL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (48) : 11653 - 11659
[8] Amphiphilic core-shell nanospheres obtained by intramicellar shell crosslinking of polymer micelles with poly(ethylene oxide) linkers
Huang, HY
Remsen, EE
Wooley, KL
[J]. CHEMICAL COMMUNICATIONS, 1998, (13) : 1415 - 1416
[9] A novel synthesis of semitelechelic functional poly(methacrylate)s through an alcoholate initiated polymerization. Synthesis of poly[2-(N,N-diethylaminoethyl) methacrylate] macromonomer
Nagasaki, Y
Sato, Y
Kato, M
[J]. MACROMOLECULAR RAPID COMMUNICATIONS, 1997, 18 (09) : 827 - 835
[10] Napper D H, 1983, POLYM STABILIZATION

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