Bisphosphonates and periodontics: Potential applications for regulation of bone mass in the periodontium and other therapeutic/diagnostic uses

被引:59
作者
Tenenbaum, HC [1 ]
Shelemay, A [1 ]
Girard, B [1 ]
Zohar, R [1 ]
Fritz, PC [1 ]
机构
[1] Univ Toronto, Fac Dent, Toronto, ON M5G 1G6, Canada
关键词
bone regeneration; bisphosphonates; etidronate/therapeutic use; osteoblasts; osteoclasts; periodontal diseases/prevention and control;
D O I
10.1902/jop.2002.73.7.813
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Bisphosphonates are widely utilized in the management of systemic metabolic bone disease due to their ability to inhibit bone resorption. Recently, new uses of this unique class of pharmacological agents have been suggested. Given their known affinity to bone and their ability to increase osteoblastic differentiation and inhibit osteoclast recruitment and activity, there exists a possible use for bisphosphonates in the diagnosis and management of periodontal diseases. These bone-specific properties could also provide an interesting management strategy to stimulate osteogenesis in conjunction with regenerative materials around osseous defects and may also result in the promotion of bone formation around endosseous implants. The objective of this article is to review the scientific evidence regarding the potential applications of bisphosphonate drugs in the therapeutic management of periodontal diseases. Moreover, the mechanism of action and the pharmacology of these drugs will be reviewed. Finally, the potential role of bisphosphonates regarding their potential to accelerate bone formation, in addition to their usual uses for inhibition of bone resorption, is discussed.
引用
收藏
页码:813 / 822
页数:10
相关论文
共 81 条
[1]   THE ACUTE-PHASE RESPONSE AFTER BISPHOSPHONATE ADMINISTRATION [J].
ADAMI, S ;
BHALLA, AK ;
DORIZZI, R ;
MONTESANTI, F ;
ROSINI, S ;
SALVAGNO, G ;
LOCASCIO, V .
CALCIFIED TISSUE INTERNATIONAL, 1987, 41 (06) :326-331
[2]   Cigar, pipe, and cigarette smoking as risk factors for periodontal disease and tooth loss [J].
Albandar, JM ;
Streckfus, CE ;
Adesanya, MR ;
Winn, DM .
JOURNAL OF PERIODONTOLOGY, 2000, 71 (12) :1874-1881
[3]   THE SIGNIFICANCE OF MAINTENANCE CARE IN THE TREATMENT OF PERIODONTAL-DISEASE [J].
AXELSSON, P ;
LINDHE, J .
JOURNAL OF CLINICAL PERIODONTOLOGY, 1981, 8 (04) :281-294
[4]   ALENDRONATE DISTRIBUTED ON BONE SURFACES INHIBITS OSTEOCLASTIC BONE-RESORPTION IN-VITRO AND IN EXPERIMENTAL HYPERCALCEMIA MODELS [J].
AZUMA, Y ;
SATO, H ;
OUE, Y ;
OKABE, K ;
OHTA, T ;
TSUCHIMOTO, M ;
KIYOKI, M .
BONE, 1995, 16 (02) :235-245
[5]   Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro [J].
Benford, HL ;
McGowan, NWA ;
Helfrich, MH ;
Nuttall, ME ;
Rogers, MJ .
BONE, 2001, 28 (05) :465-473
[6]   The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease - A prospective, controlled clinical trial [J].
Berglundh, T ;
Krok, L ;
Liljenberg, B ;
Westfelt, E ;
Serino, G ;
Lindhe, J .
JOURNAL OF CLINICAL PERIODONTOLOGY, 1998, 25 (05) :354-362
[7]   Effectiveness of local delivery of alendronate in reducing alveolar bone loss following periodontal surgery in rats [J].
Binderman, I ;
Adut, M ;
Yaffe, A .
JOURNAL OF PERIODONTOLOGY, 2000, 71 (08) :1236-1240
[8]   STUDIES IN ALTERATION OF VESTIBULAR DEPTH .1. COMPLETE DENUDATION [J].
BOHANNAN, HM .
JOURNAL OF PERIODONTOLOGY, 1962, 33 (02) :120-&
[9]   EFFECTS OF A BISPHOSPHONATE ON EXPERIMENTAL PERIODONTITIS IN MONKEYS [J].
BRUNSVOLD, MA ;
CHAVES, ES ;
KORNMAN, KS ;
AUFDEMORTE, TB ;
WOOD, R .
JOURNAL OF PERIODONTOLOGY, 1992, 63 (10) :825-830
[10]   Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis [J].
Chavassieux, PM ;
Arlot, ME ;
Reda, C ;
Wei, L ;
Yates, AJ ;
Meunier, PJ .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (06) :1475-1480