Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

被引:917
作者
Bodine, Sue C. [1 ,2 ,3 ,4 ,5 ]
Baehr, Leslie M. [4 ]
机构
[1] Univ Calif Davis, Dept Neurobiol, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Physiol, Davis, CA 95616 USA
[3] Univ Calif Davis, Dept Behav & Physiol, Davis, CA 95616 USA
[4] Univ Calif Davis, Dept Membrane Biol, Davis, CA 95616 USA
[5] Northern Calif Vet Affairs Hlth Syst, Mather, CA USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2014年 / 307卷 / 06期
关键词
muscle RING finger 1; muscle atrophy F-box; muscle sparing; ubiquitin proteasome system; atrogenes; protein quality control; RING FINGER 1; OBSTRUCTIVE PULMONARY-DISEASE; FOXO TRANSCRIPTION FACTORS; F-BOX PROTEINS; MYOSTATIN GENE-EXPRESSION; TIBIALIS-ANTERIOR MUSCLE; MESSENGER-RNA EXPRESSION; KAPPA-B ACTIVATION; TUMOR-BEARING MICE; SARCOMERIC M-LINE;
D O I
10.1152/ajpendo.00204.2014
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased transcriptionally in skeletal muscle under atrophy-inducing conditions, making them excellent markers of muscle atrophy. In the past 10 years much has been published about MuRF1 and MAFbx with respect to their mRNA expression patterns under atrophy-inducing conditions, their transcriptional regulation, and their putative substrates. However, much remains to be learned about the physiological role of both genes in the regulation of mass and other cellular functions in striated muscle. Although both MuRF1 and MAFbx are enriched in skeletal, cardiac, and smooth muscle, this review will focus on the current understanding of MuRF1 and MAFbx in skeletal muscle, highlighting the critical questions that remain to be answered.
引用
收藏
页码:E469 / E484
页数:16
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