Limited infection upon human exposure to a recombinant raccoon pox vaccine vector

被引：10

作者：

Rocke, TE

Dein, FJ

Fuchsberger, M

Fox, BC

Stinchcomb, DT

Osorio, JE

机构：

[1] USGS, Natl Wildlife Hlth Ctr, Madison, WI 53711 USA

[2] UW Dept Med, Div Infect Dis, Madison, WI 53705 USA

[3] Heska Corp, Ft Collins, CO 80525 USA

[4] PowderJect Vaccines, Middleton, WI 53562 USA

来源：

VACCINE | 2004年 / 22卷 / 21-22期

关键词：

raccoon poxvirus; viral vector; Yersinia pestis;

D O I：

10.1016/j.vaccine.2004.01.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A laboratory accident resulted in human exposure to a recombinant raccoon poxvirus (RCN) developed as a vaccine vector for antigens of Yersinia pestis for protection of wild rodents (and other animals) against plague. Within 9 days, the patient developed a small blister that healed within 4 weeks. Raccoon poxvirus was cultured from the lesion, and the patient developed antibody to plague antigen (171) and RCN. This is the first documented case of human exposure to RCN. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2757 / 2760

页数：4

共 14 条

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