E2F3 - A novel repressor of the ARF/p53 pathway

被引：51

作者：

Ginsberg, D ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

来源：

DEVELOPMENTAL CELL | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1016/j.devcel.2004.05.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The Arf tumor suppressor is a key component of the p53 tumor surveillance pathway, and its expression is activated by abnormal proliferation signals. In a recent paper, Lees and coworkers investigate the regulation of Arf expression by E2Fs and demonstrate that in normal cells E2F3 is a pivotal repressor of Arf.

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收藏

页码：742 / 743

页数：2

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