The mystery of PCSK9

[1] Mutations in PCSK9 cause autosomal dominant hypercholesterolemia [J]. NATURE GENETICS, 2003, 34 (02) : 154 - 156

[2] METABOLIC STUDIES IN FAMILIAL HYPERCHOLESTEROLEMIA - EVIDENCE FOR A GENE-DOSAGE EFFECT INVIVO [J]. JOURNAL OF CLINICAL INVESTIGATION, 1979, 64 (02) : 524 - 533

[3] INCREASED HEPATIC SECRETION OF VERY-LOW-DENSITY-LIPOPROTEIN APOLIPOPROTEIN B-100 IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA - A STABLE-ISOTOPE STUDY [J]. ATHEROSCLEROSIS, 1995, 113 (01) : 79 - 89

[4] Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (08) : 1454 - 1459

[5] Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1 [J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (11) : 1695 - 1702

[6] Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein [J]. SCIENCE, 2001, 292 (5520) : 1394 - 1398

[7] Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (07) : 1067 - 1076

[8] Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) : 12027 - 12032

[9] JAMES RW, 1989, J LIPID RES, V30, P159

[10] JANUS ED, 1980, EUR J CLIN INVEST, V10, P149, DOI 10.1111/j.1365-2362.1980.tb02075.x

[1] Mutations in PCSK9 cause autosomal dominant hypercholesterolemia [J]. NATURE GENETICS, 2003, 34 (02) : 154 - 156

[2] METABOLIC STUDIES IN FAMILIAL HYPERCHOLESTEROLEMIA - EVIDENCE FOR A GENE-DOSAGE EFFECT INVIVO [J]. JOURNAL OF CLINICAL INVESTIGATION, 1979, 64 (02) : 524 - 533

[3] INCREASED HEPATIC SECRETION OF VERY-LOW-DENSITY-LIPOPROTEIN APOLIPOPROTEIN B-100 IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA - A STABLE-ISOTOPE STUDY [J]. ATHEROSCLEROSIS, 1995, 113 (01) : 79 - 89

[4] Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (08) : 1454 - 1459

[5] Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1 [J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (11) : 1695 - 1702

[6] Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein [J]. SCIENCE, 2001, 292 (5520) : 1394 - 1398

[7] Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (07) : 1067 - 1076

[8] Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) : 12027 - 12032

[9] JAMES RW, 1989, J LIPID RES, V30, P159

[10] JANUS ED, 1980, EUR J CLIN INVEST, V10, P149, DOI 10.1111/j.1365-2362.1980.tb02075.x