Human fronto-mesolimbic networks guide decisions about charitable donation

被引:549
作者
Moll, Jorge
Krueger, Frank
Zahn, Roland
Pardini, Matteo
de Oliveira-Souzat, Ricardo
Grafman, Jordan
机构
[1] NINDS, Cognit Neurosci Sect, NIH, Bethesda, MD 20892 USA
[2] Hosp Network, Cognit & Behav Neurosci Unit, LABS, Rio De Janeiro, Brazil
[3] Univ Genoa, Sch Med, I-16132 Genoa, Italy
[4] Gaffree & Guinle Univ Hos, BR-20270004 Rio De Janeiro, Brazil
[5] Philippe Pinel Inst, BR-20270004 Rio De Janeiro, Brazil
关键词
altruism; brain; moral; reward; social;
D O I
10.1073/pnas.0604475103
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Humans often sacrifice material benefits to endorse or to oppose societal causes based on moral beliefs. Charitable donation behavior, which has been the target of recent experimental economics studies, is an outstanding contemporary manifestation of this ability. Yet the neural bases of this unique aspect of human altruism, which extends beyond interpersonal interactions, remain obscure. In this article, we use functional magnetic resonance imaging while participants anonymously donated to or opposed real charitable organizations related to major societal causes. We show that the mesolimbic reward system is engaged by donations in the same way as when monetary rewards are obtained. Furthermore, medial orbitofrontal-subgenual and lateral orbitofrontal areas, which also play key roles in more primitive mechanisms of social attachment and aversion, specifically mediate decisions to donate or to oppose societal causes. Remarkably, more anterior sectors of the prefrontal cortex are distinctively recruited when altruistic choices prevail over selfish material interests.
引用
收藏
页码:15623 / 15628
页数:6
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