Osteoclasts activation by bacterial endotoxins during periodontal diseases

被引：4

作者：

Doucet, Philippe ^{[1
]}

Lowenstein, Morgan ^{[1
]}

机构：

[1] Univ Paris 05, Fac Chirurg Dentaire, Lab Reparat & Remodelages Orofaciaux, EA2496, F-92120 Montrouge, France

来源：

M S-MEDECINE SCIENCES | 2006年 / 22卷 / 6-7期

关键词：

D O I：

10.1051/medsci/20062267614

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

During periodontal infections, bacterial lipopolysaccharides (LPS) from Gram negative bacteria, along with other bacterial products, drive alveolar bone destruction. Tissue destruction occurs through both direct and indirect pathways. In the indirect pathway, LPS induce the secretion of proinflammatory cytokines, which in turn provokes a cascade of reactions leading to osteoclasts activation. In the direct pathway, LPS stimulate osteoblasts, osteoclasts precursors and osteoclasts, with an inflammatory cytokines independent manner. In this paper, the mechanisms involved in these two pathways are reviewed.

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收藏

页码：614 / 618

页数：5

相关论文

共 27 条

[1]

CD4+ T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice [J].

Baker, PJ ;

Dixon, M ;

Evans, RT ;

Dufour, L ;

Johnson, E ;

Roopenian, DC .

INFECTION AND IMMUNITY, 1999, 67 (06) :2804-2809

[2]

RANK ligand and the regulation of skeletal remodeling [J].

Bell, NH .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (08) :1120-1122

[3]

Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans [J].

Chaudhary, PM ;

Ferguson, C ;

Nguyen, V ;

Nguyen, O ;

Massa, HF ;

Eby, M ;

Jasmin, A ;

Trask, BJ ;

Hood, L ;

Nelson, PS .

BLOOD, 1998, 91 (11) :4020-4027

[4]

Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction [J].

Chow, JC ;

Young, DW ;

Golenbock, DT ;

Christ, WJ ;

Gusovsky, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :10689-10692

[5]

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells [J].

Hofbauer, LC ;

Lacey, DL ;

Dunstan, CR ;

Spelsberg, TC ;

Riggs, BL ;

Khosla, S .

BONE, 1999, 25 (03) :255-259

[6]

Lipopolysaccharide promotes the survival of osteoclasts via Toll-like receptor 4, but cytokine production of osteoclasts in response to lipopolysaccharide is different from that of macrophages [J].

Itoh, K ;

Udagawa, N ;

Kobayashi, K ;

Suda, K ;

Li, XT ;

Takami, M ;

Okahashi, N ;

Nishihara, T ;

Takahashi, N .

JOURNAL OF IMMUNOLOGY, 2003, 170 (07) :3688-3695

[7]

Jimi E, 1999, J IMMUNOL, V163, P434

[8]

Josien R, 1999, J IMMUNOL, V162, P2562

[9]

Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease [J].

Kawai, T ;

Eisen-Lev, R ;

Seki, M ;

Eastcott, JW ;

Wilson, ME ;

Taubman, MA .

JOURNAL OF IMMUNOLOGY, 2000, 164 (04) :2102-2109

[10]

Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via toll-like receptors [J].

Kikuchi, T ;

Matsuguchi, T ;

Tsuboi, N ;

Mitani, A ;

Tanaka, S ;

Matsuoka, M ;

Yamamoto, G ;

Hishikawa, T ;

Noguchi, T ;

Yoshikai, Y .

JOURNAL OF IMMUNOLOGY, 2001, 166 (05) :3574-3579