Borrelia burgdorferi infection: Clinical diagnostic techniques

被引:10
作者
Coyle, PK
机构
[1] Department of Neurology, School of Medicine, State Univ. New York at Stony Brook, Stony Brook
关键词
LYME-DISEASE SPIROCHETE; CENTRAL-NERVOUS-SYSTEM; SURFACE PROTEIN-C; ERYTHEMA MIGRANS; CEREBROSPINAL-FLUID; SEROLOGIC TESTS; SENSU-STRICTO; ANTIBODY; INVASION; SERODIAGNOSIS;
D O I
10.3109/08820139709048920
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Borrelia burgdorferi is a tick-borne spirochete and the etiologic agent of Lyme disease. This pathogen now accounts for 91% of vector-borne infections in the United States, and from a public health viewpoint is one of our major emerging infectious disorders. Specific properties of B. burgdorferi have resulted in diagnostic problems, including the lack of a readily available laboratory assay to detect active infection. Most laboratory testing for Lyme disease relies on serologic documentation of prior exposure to the agent. However, such testing detects asymptomatic infections, and does not detect seronegative infections. In addition, antibody tests for Lyme disease are not standardized. Cases of Lyme disease are both underdiagnosed and overdiagnosed. This review will discuss the spirochetal properties which contribute to diagnostic difficulties, wilt discuss current laboratory diagnostic tests, including serology and detection of B. burgdorferi DNA, and will discuss diagnostic tests in development, including recombinant-based serologic assays and detection of B. burgdorferi antigens.
引用
收藏
页码:117 / 128
页数:12
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