βCCM enhances retrieval of serial contextual but not of serial spatial memory in mice

被引:7
作者
Celerier, A
Pierard, C
Beracochea, D
机构
[1] Univ Bordeaux 1, Cognit Neurosci Lab, UMR 5106, CNRS, F-33045 Talence, France
[2] Univ Montpellier 2, Lab Plast Cerebrale, Montpellier, France
[3] IMASSA, Dept Physiol, Bretigny Sur Orge, France
来源
BEHAVIOURAL PHARMACOLOGY | 2004年 / 15卷 / 02期
关键词
contextual retrieval; spatial retrieval; beta CCM; memory; mouse;
D O I
10.1097/00008877-200403000-00004
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of inverse agonists of the gamma-aminobutyric acid (GABA)/benzodiazepine receptors such as beta-carboline-3-carboxylate (betaCCM) on retrieval processes have not been studied extensively. This study investigates the effects in mice of an acute betaCCM injection on retrieval of previously acquired serial discriminations, involving distinct contextual cues (Contextual Serial Discrimination, CSD) or identical cues (Serial Spatial Discrimination, SSD) in a four-hole board. Animals submitted to CSD were also evaluated for emotional reactivity in an elevated-plus maze. In both the CSD and the SSD tasks, mice were injected with saline before the learning session began. Twenty-four hours later, mice were replaced on the hole-board following a single dose of saline or betaCCM (0.5 mg/kg or 1.5 mg/kg) injected 20 min before testing. The highest dose of betaCCM improved performance of the first discrimination in the contextual task but not in the spatial task. Moreover, the higher dose of betaCCM produced anxiety-like reactivity in an elevated-plus maze, and scores of 'anxiety' were positively correlated with memory scores. Overall, the data show that the betaCCM enhancement of memory processes depends on: (1) the cues associated with the to-be-remembered information; and (2) the emotional effects of the drug.
引用
收藏
页码:123 / 131
页数:9
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