Placental leptin

被引：107

作者：

Ashworth, CJ ^{[1
]}

Hoggard, N ^{[1
]}

Thomas, L ^{[1
]}

Mercer, JG ^{[1
]}

Wallace, JM ^{[1
]}

Lea, RG ^{[1
]}

机构：

[1] Rowett Res Inst, Bucksburn AB21 9SB, Aberdeen, Scotland

来源：

REVIEWS OF REPRODUCTION | 2000年 / 5卷 / 01期

关键词：

D O I：

10.1530/ror.0.0050018

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Placental tissues from humans, rodents and farm animals contain leptin and its receptor. Leptin produced by the human placenta has the same size, charge and immunoreactivity as leptin produced by adipose tissue. However, the expression of human placental leptin appears to be regulated by a placenta-specific upstream enhancer. In this review the occurrence of leptin and its receptor in a range of species and placental types is described, and its significance during pregnancy discussed. Placental leptin contributes to the increase in maternal circulating concentrations of leptin during late pregnancy when it is likely to have an endocrine role in regulating maternal energy balance. Placental leptin may have angiogenic and immunomodulatory activities, which affect the placenta in an autocrine or paracrine manner. It also appears to affect fetal growth and development by binding to leptin receptors present in fetal organs.

引用

页码：18 / 24

页数：7

共 39 条

[1]

ASHWORTH CJ, 1998, J REPRODUCTION FERTI, V22

[2] A role for leptin and its cognate receptor in hematopoiesis [J].

Bennett, BD ;

Solar, GP ;

Yuan, JQ ;

Mathias, J ;

Thomas, GR ;

Matthews, W .

CURRENT BIOLOGY, 1996, 6 (09) :1170-1180

[3] Identification of a placental enhancer for the human leptin gene [J].

Bi, S ;

Gavrilova, O ;

Gong, DW ;

Mason, MM ;

Reitman, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) :30583-30588

[4] Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin [J].

Chehab, FE ;

Lim, ME ;

Lu, RH .

NATURE GENETICS, 1996, 12 (03) :318-320

[5] Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats [J].

Chien, EK ;

Hara, M ;

Rouard, M ;

Yano, H ;

Phillippe, M ;

Polonsky, KS ;

Bell, GI .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 237 (02) :476-480

[6]

Clarke IJ, 1999, REV REPROD, V4, P48

[7] Leptin's actions on the reproductive axis: Perspectives and mechanisms [J].

Cunningham, MJ ;

Clifton, DK ;

Steiner, RA .

BIOLOGY OF REPRODUCTION, 1999, 60 (02) :216-222

[8] Physiological perspectives on leptin as a regulator of reproduction: Role in timing puberty [J].

Foster, DL ;

Nagatani, S .

BIOLOGY OF REPRODUCTION, 1999, 60 (02) :205-215

[9] Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor [J].

Gavrilova, O ;

Barr, V ;

MarcusSamuels, B ;

Reitman, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) :30546-30551

[10] Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation [J].

Gómez, L ;

Carrascosa, A ;

Yeste, D ;

Potau, N ;

Riqué, S ;

Ruiz-Cuevas, P ;

Almar, J .

HORMONE RESEARCH, 1999, 51 (01) :10-14

← 1 2 3 4 →