Human B-cell lymphoma cell lines are highly sensitive to apoptosis induced by all-trans retinoic acid and interferon-γ

被引：12

作者：

Niitsu, N

Higashihara, M

Honma, Y

机构：

[1] Kitasato Univ, Sch Med, Dept Hematol & Internal Med 4, Sagamihara, Kanagawa 2288555, Japan

[2] Saitama Canc Ctr, Ina, Saitama, Japan

来源：

LEUKEMIA RESEARCH | 2002年 / 26卷 / 08期

关键词：

B-cell lymphoma; interferon-gamma; all-trans retinoic acid; apoptosis;

D O I：

10.1016/S0145-2126(01)00202-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. The concentration of IFN-gamma that effectively inhibited the proliferation of BALM-3 cells was 1/40 of that required for BALM-I cells. STAT-I phosphorylation, IRF-I mRNA and protein expression and RAR-beta expression were enhanced to a greater degree in BALM-3 cells treated with IFN-gamma and ATRA than in BALM-I cells treated with IFN-gamma and ATRA, suggesting that these IFN-gamma related genes were involved in the induction of apoptosis of BALM-3 cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：745 / 755

页数：11

共 48 条

[1]

Enhancement of HL-60 differentiation by a new class of retinoids with selective activity on retinoid X receptor [J].