Efficient palladium-catalyzed direct arylation of azines and diazines using ligand-free conditions

被引：44

作者：

Baso, Luca ^{[1
]}

Beccalli, Egle M. ^{[1
]}

Borsini, Elena ^{[2
]}

Broggini, Gianluigi ^{[2
]}

机构：

[1] Univ Milan, Fac Farm, Ist Chim Organ A Marchesini, I-20133 Milan, Italy

[2] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

来源：

TETRAHEDRON | 2009年 / 65卷 / 17期

关键词：

PROTON-ABSTRACTION MECHANISM; ARYL CHLORIDES; POTENT; CYCLIZATION; BOND; INHIBITORS; DISCOVERY; BROMIDES; ANALOGS;

D O I：

10.1016/j.tet.2009.02.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of the palladium-catalyzed direct arylation was successfully tested on different electron-deficient heterocycles. The results demonstrate the effectiveness of the method based on the intramolecular coupling reaction providing polyazacyclic systems. This new application was obtained by using ligand-free conditions with the mixture of Pd(OAc)(2) and TBAC as catalytic system. With suitable substrates different products arising from regioselective coupling were observed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3486 / 3491

页数：6

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