Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder

被引：51

作者：

Cohen-Woods, Sarah ^{[1
]}

Gaysina, Daria ^{[1
]}

Craddock, Nick ^{[2
]}

Farmer, Anne ^{[1
]}

Gray, Joanna ^{[1
]}

Gunasinghe, Cerisse ^{[1
]}

Hoda, Farzana ^{[1
]}

Jones, Lisa ^{[3
]}

Knight, Jo ^{[1
]}

Korszun, Ania ^{[4
]}

Owen, Michael J. ^{[2
]}

Sterne, Abram ^{[1
]}

Craig, Ian W. ^{[1
]}

McGuffin, Peter ^{[1
]}

机构：

[1] Kings Coll London, MRC, SGDP Ctr, Inst Psychiat, London SES 8AF, England

[2] Cardiff Univ, Dept Psychol Med, Sch Med, Cardiff CF14 4XN, S Glam, Wales

[3] Univ Birmingham, Div Neurosci, Dept Psychiat, Birmingham B15 2FG, W Midlands, England

[4] Wolfson Inst Prevent Med, Ctr Psychiat, London EC1M 6BQ, England

来源：

HUMAN MOLECULAR GENETICS | 2009年 / 18卷 / 08期

基金：

奥地利科学基金会; 英国医学研究理事会;

关键词：

ALCOHOL DEPENDENCE; ALZHEIMERS-DISEASE; ASSOCIATION; PSYCHOPATHOLOGY; SAMPLE; CORTEX; RISK; MAIL; MICE; DNA;

D O I：

10.1093/hmg/ddp051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case-control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.

引用

页码：1504 / 1509

页数：6

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