CAPS: coevolution analysis using protein sequences

被引：102

作者：

Fares, Mario A. ^{[1
]}

McNally, David ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Smurfit Inst Genet, Dept Genet, Evolut Genet & Bioinformat Lab, Dublin 2, Ireland

来源：

BIOINFORMATICS | 2006年 / 22卷 / 22期

基金：

爱尔兰科学基金会;

关键词：

D O I：

10.1093/bioinformatics/btl493

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Coevolution Analysis using Protein Sequences (CAPS) is a PERL based software that identifies co-evolution between amino acid sites. Blosum-corrected amino acid distances are used to identify amino acid co-variation. The phylogenetic sequence relationships are used to remove the phylogenetic and stochastic dependencies between sites. The 3D protein structure is used to identify the nature of the dependencies between co-evolving amino acid sites. Friendly interpretable output files are generated. Availability: CAPS version 1 is available at http://bioinf.gen.tcd.ie/similar to faresm/software/caps/.Distribution versions for Linux/Unix, Mac OS X and Windows operating systems are available, including manual and example files. Contact: faresm@tcd.ie.

引用

页码：2821 / 2822

页数：2

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