Visualizing the first 50 Hr of the primary immune response to a soluble antigen

被引：140

作者：

Catron, DM ^{[1
]}

Itano, AA

Pape, KA

Mueller, DL

Jenkins, MK

机构：

[1] Univ Minnesota, Sch Med, Dept Microbiol, Ctr Immunol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Med, Ctr Immunol, Minneapolis, MN 55455 USA

来源：

IMMUNITY | 2004年 / 21卷 / 03期

关键词：

D O I：

10.1016/j.immuni.2004.08.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Recently, static and dynamic imaging methods have produced the first glimpses of the interactions between antigen-specific T cells and peptide-MHC-bearing antigen-presenting cells in the lymph nodes. Using data from these experiments, we produced a numerically, spatially, and temporally scaled simulation of the first 50 hr of the primary T cell-dependent immune response. The simulation highlights how lymph node structure facilitates antigen presentation to rare, naive, antigen-specific CD4+ T cells.

引用

页码：341 / 347

页数：7

共 41 条

[1]

A chemokine-driven positive feedback loop organizes lymphoid follicles [J].

Ansel, KM ;

Ngo, VN ;

Hyman, PL ;

Luther, SA ;

Förster, R ;

Sedgwick, JD ;

Browning, JL ;

Lipp, M ;

Cyster, JG .

NATURE, 2000, 406 (6793) :309-314

[2]

The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation [J].

Bajénoff, M ;

Granjeaud, S ;

Guerder, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (05) :715-724

[3]

Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4+ T cells [J].

Bajénoff, M ;

Wurtz, O ;

Guerder, S .

JOURNAL OF IMMUNOLOGY, 2002, 168 (04) :1723-1729

[4]

Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes [J].

Bousso, P ;

Robey, E .

NATURE IMMUNOLOGY, 2003, 4 (06) :579-585

[5]

COMPETITION FOR FOLLICULAR NICHES EXCLUDES SELF-REACTIVE CELLS FROM THE RECIRCULATING B-CELL REPERTOIRE [J].

CYSTER, JG ;

HARTLEY, SB ;

GOODNOW, CC .

NATURE, 1994, 371 (6496) :389-395

[6]

Cutting edge:: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling [J].

Faroudi, M ;

Zaru, R ;

Paulet, P ;

Müller, S ;

Valitutti, S .

JOURNAL OF IMMUNOLOGY, 2003, 171 (03) :1128-1132

[7]

FORD WL, 1969, SEMIN HEMATOL, V6, P67

[8]

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help [J].

Fulcher, DA ;

Lyons, AB ;

Korn, SL ;

Cook, MC ;

Koleda, C ;

Parish, C ;

Fazekas de St Groth, B ;

Basten, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (05) :2313-2328

[9]

Visualization of specific B and T lymphocyte interactions in the lymph node [J].

Garside, P ;

Ingulli, E ;

Merica, RR ;

Johnson, JG ;

Noelle, RJ ;

Jenkins, MK .

SCIENCE, 1998, 281 (5373) :96-99

[10]

In vivo antigen presentation [J].

Germain, RN ;

Jenkins, MK .

CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (01) :120-125

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