Diversity in guanine-selective DNA binding modes for an organometallic ruthenium arene complex

被引：143

作者：

Liu, Hong-Ke

Berners-Price, Susan J.

Wang, Fuyi

Parkinson, John A.

Xu, Jingjing

Bella, Juraj

Sadler, Peter J.

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] Nanjing Normal Univ, Sch Chem & Environm Sci, Nanjing 210046, Peoples R China

[3] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Nedlands, WA 6009, Australia

[4] Univ Strathclyde, Dept Pure & Appl Chem, WestChem, Glasgow G1 1XL, Lanark, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 48期

关键词：

anticancer agents; bioinorganic chemistry; DNA; NMR spectroscopy; ruthenium;

D O I：

10.1002/anie.200602873

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Seek and hide! An organometallic ruthenium arene anticancer complex with ruthenium (pink ball) chelated by ethylenediamine (blue) is selective for guanine bases on DNA and can bury the non-coordinated phenyl ring of its arene ligand (yellow) between bases in the double helix. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：8153 / 8156

页数：4

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