Lipoprotein oxidation in cardiovascular disease: chief culprit or innocent bystander?

被引：64

作者：

Heinecke, JW ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 04期

关键词：

D O I：

10.1084/jem.20060218

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Oxidation of low-density lipoprotein (LDL) is thought to contribute to atherosclerosis and cardiovascular disease. Consistent with this idea, the antioxidant drug probucol reduces the risk of restenosis, a form of cardiovascular disease, in humans. However, a new study now suggests that the protective effect of probucol depends not on its ability to inhibit lipid oxidation, but on its ability to induce the stress-induced antiinflammatory enzyme heme oxygenase (HO)-1. This might explain why other antioxidants, such as vitamin E, fail to prevent cardiovascular disease in humans.

引用

收藏

页码：813 / 816

页数：4

相关论文

共 28 条

[1]

BERGT C, P NATL ACAD SCI US, V10, P13032

[2]

Increased atherosclerosis in myeloperoxidase-deficient mice [J].

Brennan, ML ;

Anderson, MM ;

Shih, DM ;

Qu, XD ;

Wang, XP ;

Mehta, AC ;

Lim, LL ;

Shi, WB ;

Hazen, SL ;

Jacob, JS ;

Crowley, JR ;

Heinecke, JW ;

Lusis, AJ .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (04) :419-430

[3]

ANTIATHEROGENIC EFFECT OF PROBUCOL UNRELATED TO ITS HYPOCHOLESTEROLEMIC EFFECT - EVIDENCE THAT ANTIOXIDANTS INVIVO CAN SELECTIVELY INHIBIT LOW-DENSITY-LIPOPROTEIN DEGRADATION IN MACROPHAGE-RICH FATTY STREAKS AND SLOW THE PROGRESSION OF ATHEROSCLEROSIS IN THE WATANABE HERITABLE HYPERLIPIDEMIC RABBIT [J].

CAREW, TE ;

SCHWENKE, DC ;

STEINBERG, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7725-7729

[4]

MYELOPEROXIDASE, A CATALYST FOR LIPOPROTEIN OXIDATION, IS EXPRESSED IN HUMAN ATHEROSCLEROTIC LESIONS [J].

DAUGHERTY, A ;

DUNN, JL ;

RATERI, DL ;

HEINECKE, JW .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :437-444

[5]

DENG YM, CIRCULATION, V110, P1855

[6]

MALONDIALDEHYDE-ALTERED PROTEIN OCCURS IN ATHEROMA OF WATANABE HERITABLE HYPERLIPIDEMIC RABBITS [J].

HABERLAND, ME ;

FONG, D ;

CHENG, L .

SCIENCE, 1988, 241 (4862) :215-218

[7]

alpha-tocopherol does not inhibit hypochlorite-induced oxidation of apolipoprotein B-100 of low-density lipoprotein [J].

Hazell, LJ ;

Stocker, R .

FEBS LETTERS, 1997, 414 (03) :541-544

[8]

Presence of hypochlorite-modified proteins in human atherosclerotic lesions [J].

Hazell, LJ ;

Arnold, L ;

Flowers, D ;

Waeg, G ;

Malle, E ;

Stocker, R .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (06) :1535-1544

[9]

3-chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima [J].

Hazen, SL ;

Heinecke, JW .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (09) :2075-2081

[10]

IRON AND COPPER PROMOTE MODIFICATION OF LOW-DENSITY LIPOPROTEIN BY HUMAN ARTERIAL SMOOTH-MUSCLE CELLS IN CULTURE [J].

HEINECKE, JW ;

ROSEN, H ;

CHAIT, A .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (05) :1890-1894