Protective effect of KB-R7943, a novel Na+/Ca2+ exchange inhibitor, on ischemic acute renal failure in rats

被引：14

作者：

Kuro, T ^{[1
]}

Kobayashi, Y ^{[1
]}

Takaoka, M ^{[1
]}

Matsumura, Y ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Dept Pharmacol, Takatsuki, Osaka 5691094, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1999年 / 81卷 / 02期

关键词：

ischemic acute renal failure; Na+/Ca2+ exchanger; renal function;

D O I：

10.1254/jjp.81.247

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of KB-R7943 (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl] methanesulfonate), a novel Na+/Ca2+ exchange inhibitor, on ischemic acute renal failure (ARF) in rats were examined. ARF was induced by clamping the left renal pedicle for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function was markedly diminished in ARF rats. Pretreatment with KB-R7943 (10 mg/kg, i.v.) markedly attenuated the ARF-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damage, which was suppressed by KB-R7943. Activation of the reverse mode of Na+/Ca2+ exchange seems to play an important role in the pathogenesis of ARF. A selective Na+/Ca2+ exchange inhibitor may be useful in cases of ARF.

引用

页码：247 / 251

页数：5

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