Spontaneous generation of multilamellar vesicles from ethylene oxide/butylene oxide diblock copolymers

被引:57
作者
Harris, JK [1 ]
Rose, GD
Bruening, ML
机构
[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA
[2] Dow Chem Co USA, Corp Res & Dev, Midland, MI 48674 USA
关键词
D O I
10.1021/la015714h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Vesicular structures are promising materials for encapsulation applications, and vesicles composed from block copolymers are attractive in this regard because of their stability and tunability. However, vesicle formation from copolymers generally requires specialized procedures. This article demonstrates that ethylene oxide/butylene oxide diblock copolymers spontaneously form micrometer-sized, multilamellar vesicles ("onions") over a broad range of concentrations upon simple mixing with water. These structures likely form due to the relatively large volume-to-length ratio of the butylene oxide hydrophobe, and vesicle formation also depends on the length of the ethylene oxide headgroup. Structures were characterized using plane-polarized light microscopy, dynamic light scattering, and cryogenic scanning electron microscopy. The multilamellar vesicles survive sonication and moderate shear. Vesicle size can be reduced by extrusion through a porous membrane, but final diameter is independent of shear rate and membrane pore size.
引用
收藏
页码:5337 / 5342
页数:6
相关论文
共 35 条
[1]   Structural polymorphism of amphiphilic copolymers: Six lyotropic liquid crystalline and two solution phases in a poly(oxybutylene)-b-poly(oxyethylene)-water-xylene system [J].
Alexandridis, P ;
Olsson, U ;
Lindman, B .
LANGMUIR, 1997, 13 (01) :23-34
[2]   Nano-engineering block copolymer aggregates for drug delivery [J].
Allen, C ;
Maysinger, D ;
Eisenberg, A .
COLLOIDS AND SURFACES B-BIOINTERFACES, 1999, 16 (1-4) :3-27
[3]  
BAILEY FE, 1987, NONIONIC SURFACTANTS, P929
[4]   Behavior of a charged vesicle system under the influence of a shear gradient: A microstructural study [J].
Bergmeier, M ;
Gradzielski, M ;
Hoffmann, H ;
Mortensen, K .
JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (16) :2837-2840
[5]  
CLINT JH, 1992, SURFACTANT AGGREGATI, P23
[6]  
Collings P. J., 1990, LIQ CRYST, P90
[7]   Micelles and gels of oxyethylene-oxybutylene diblock copolymers in aqueous solution: The effect of oxyethylene-block length [J].
Derici, L ;
Ledger, S ;
Mai, SM ;
Booth, C ;
Hamley, IW ;
Pedersen, JS .
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 1999, 1 (11) :2773-2785
[8]   Water-soluble hollow nanospheres as potential drug carriers [J].
Ding, JF ;
Liu, GJ .
JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (31) :6107-6113
[9]   Polymersomes: Tough vesicles made from diblock copolymers [J].
Discher, BM ;
Won, YY ;
Ege, DS ;
Lee, JCM ;
Bates, FS ;
Discher, DE ;
Hammer, DA .
SCIENCE, 1999, 284 (5417) :1143-1146
[10]  
DORFLER HD, 1993, TENSIDE SURFACT DET, V30, P3