Lack of relationship between cellular density and either capillary density or metabolic rate in different regions of the brain

被引：11

作者：

Baborie, Atik

Kuschinsky, Wolfgang

机构：

[1] Newcastle Gen Hosp, Dept Neuropathol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[2] Heidelberg Univ, Dept Physiol, Heidelberg, Germany

来源：

NEUROSCIENCE LETTERS | 2006年 / 404卷 / 1-2期

关键词：

cellularity; brain; capillary; LCGU; LCBF; metabolism;

D O I：

10.1016/j.neulet.2006.05.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Whereas a pronounced correlation exists between local cerebral glucose utilization (LCGU) and capillary density in different regions of the brain, it is not known whether these parameters also correlate with the overall density of nuclei (cellularity). Therefore, cellularity was determined by diamidino-phenylindol (DAPI) fluorescent staining of nuclei in acetone-fixed frozen sections of the rat brain. A comparison of the density of nuclei in different brain regions showed much less variation than that observed in LCGU and capillary density. No correlation was found between nuclear density and either LCGU or capillary densities. In conclusion the cellular density is not a determinant of variation in LCGU and capillary density. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：20 / 22

页数：3

共 12 条

[1] METABOLIC ANATOMY OF BRAIN - A COMPARISON OF REGIONAL CAPILLARY DENSITY, GLUCOSE-METABOLISM, AND ENZYME-ACTIVITIES [J].