Memory and executive function impairment predict dementia in Parkinson's disease

被引:208
作者
Levy, G
Jacobs, DM
Tang, MX
Côté, LJ
Louis, ED
Alfaro, B
Mejia, H
Stern, Y
Marder, K
机构
[1] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA
[2] Columbia Univ, Dept Neurol, Coll Phys & Surg, New York, NY 10032 USA
[3] Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA
[4] Columbia Univ, Div Biostat, Sch Publ Hlth, New York, NY 10032 USA
[5] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA
关键词
Parkinson's disease; dementia; cognition; neuropsychological predictors;
D O I
10.1002/mds.10280
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We analyzed the association of neuropsychological test impairment at baseline with the development of dementia in idiopathic Parkinson's disease (PD) patients. A cohort of nondemented PD patients from northern Manhattan, NY was followed annually with neurological and neuropsychological evaluations. The neuropsychological battery included tests of verbal and nonverbal memory, orientation, visuospatial ability, language, and abstract reasoning. The association of baseline neuropsychological tests scores with incident dementia was analyzed using Cox proportional hazards models. The analysis controlled for age, gender, education, duration of PD, and the total Unified Parkinson's Disease Rating Scale motor score at baseline. Forty-five out of 164 patients (27%) became demented during a mean follow-up of 3.7 +/- 2.3 years. Four neuropsychological test scores were significantly associated with incident dementia in the Cox model: total immediate recall (RR: 0.92, 95% Cl: 0.87-0.97, P = 0.001) and delayed recall (RR: 0.73, 95% Cl: 0.59-0.91, P = 0.005) of the Selective Reminding Test (SRT), letter fluency (RR: 0.87, 95% Cl: 0.77-0.99, P = 0.03), and Identities and Oddities of the Mattis Dementia Rating Scale (RR: 0.85, 95% Cl: 0.73-0.98, P = 0.03). When the analysis was performed excluding patients with a clinical dementia rating of 0.5 (questionable dementia) at baseline evaluation, total immediate recall and delayed recall were still predictive of dementia in PD. Our results indicate that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD. (C) 2002 Movement Disorder Society.
引用
收藏
页码:1221 / 1226
页数:6
相关论文
共 49 条
[1]   Risk of dementia in Parkinson's disease - A community-based, prospective study [J].
Aarsland, D ;
Andersen, K ;
Larsen, JP ;
Lolk, A ;
Nielsen, H ;
Kragh-Sorensen, P .
NEUROLOGY, 2001, 56 (06) :730-736
[2]  
[Anonymous], 1981, ROSEN DRAWING TEST
[3]  
[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th
[4]  
[Anonymous], COMPREHENSIVE MANAGE
[5]   NEUROPATHOLOGICAL STAGING OF ALZHEIMER LESIONS AND INTELLECTUAL STATUS IN ALZHEIMERS AND PARKINSONS-DISEASE PATIENTS [J].
BANCHER, C ;
BRAAK, H ;
FISCHER, P ;
JELLINGER, KA .
NEUROSCIENCE LETTERS, 1993, 162 (1-2) :179-182
[6]  
Benton A., 1955, VISUAL RETENTION TES
[7]  
Benton AL., 1976, MULTILINGUAL APHASIA
[8]   A CONTROLLED, LONGITUDINAL-STUDY OF DEMENTIA IN PARKINSONS-DISEASE [J].
BIGGINS, CA ;
BOYD, JL ;
HARROP, FM ;
MADELEY, P ;
MINDHAM, RHS ;
RANDALL, JI ;
SPOKES, EGS .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (07) :566-571
[9]   ASSOCIATION BETWEEN QUANTITATIVE MEASURES OF DEMENTIA AND OF SENILE CHANGE IN CEREBRAL GREY MATTER OF ELDERLY SUBJECTS [J].
BLESSED, G ;
TOMLINSON, BE ;
ROTH, M .
BRITISH JOURNAL OF PSYCHIATRY, 1968, 114 (512) :797-+
[10]   PARKINSON DISEASE, DEMENTIA, AND ALZHEIMER-DISEASE - CLINICOPATHOLOGICAL CORRELATIONS [J].
BOLLER, F ;
MIZUTANI, T ;
ROESSMANN, U ;
GAMBETTI, P .
ANNALS OF NEUROLOGY, 1980, 7 (04) :329-335