Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes

被引：16

作者：

Shim, Jae Woong ^{[1
]}

Jo, Seong Ho ^{[1
]}

Kim, Sang Doo ^{[1
]}

Lee, Ha Young ^{[1
]}

Yun, Jeanho ^{[1
]}

Bae, Yoe-Sik ^{[1
]}

机构：

[1] Dong A Univ, Dept Biochem, Coll Med, Pusan 602714, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2009年 / 41卷 / 08期

关键词：

cell migration inhibition; chemotaxis; leukocyte; interleukin-1; beta; lysophosphatidylglycerol; phagocytes; receptors; formyl peptide; PROTEIN-COUPLED RECEPTOR; OVARIAN-CANCER CELLS; NF-KAPPA-B; PHOSPHOLIPASE A(2); RESPIRATORY BURST; HUMAN NEUTROPHILS; HUMAN MONOCYTES; IDENTIFICATION; FPRL1; ACID;

D O I：

10.3858/emm.2009.41.8.064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1 beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1 beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.

引用

页码：584 / 591

页数：8

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