Autophagy and Immune Response in Kidneys

被引:47
作者
Leventhal, Jeremy S. [1 ,2 ]
He, John C. [1 ,2 ]
Ross, Michael J. [1 ]
机构
[1] Icahn Sch Med Mt Sinai, Dept Med, Div Renal, New York, NY 10029 USA
[2] James J Peters Bronx VA Hosp, Div Renal, Bronx, NY USA
基金
美国国家卫生研究院;
关键词
Autophagy; kidney; innate immunity; acute kidney injury; inflammasome; cytokine; MHC CLASS-II; CHROMATIN PROTEIN HMGB1; HLA-DR; INTERFERON-GAMMA; IFN-GAMMA; CELLS; EXPRESSION; INDUCTION; INFLAMMATION; CONTRIBUTES;
D O I
10.1016/j.semnephrol.2013.11.008
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
100201 [内科学]; 100221 [泌尿外科学];
摘要
Autophagy is a ubiquitous intracellular catabolic process that contributes to homeostatic maintenance and regulates the balance between health and disease. Emerging evidence from both the immunology and renal literature suggests that important relationships exist between the immune system and renal autophagy that may have significant implications for our understanding of the pathogenesis of kidney diseases. Autophagic flux in renal parenchymal cells can protect against acute and chronic kidney injury and can be stimulated via activation of innate immune receptors, cytokine secretion, and/or direct contact by immune cells. Conversely, modulation of autophagy in renal cells may influence both adaptive and innate immune cell responses. Autophagy can promote the ability of renal epithelial cells, which can act as antigen-presenting cells, to process and present self-antigen to immune cells. In addition, autophagic control of inflammasome function can modify the intrarenal inflammatory milieu, thereby preventing immune cell infiltration. Because autophagy and immune responses may promote or protect against kidney injury, further research is needed to better understand how interactions between renal parenchymal cells and the immune system are altered by autophagy. Novel agents are being developed that promote or inhibit various steps of the autophagy pathway, and it is likely that whether such agents are beneficial or harmful in the context of kidney disease will depend, at least in part, on whether and how they influence the relationship between autophagy and the immune response in the kidney. (C) 2014 Published by Elsevier Inc.
引用
收藏
页码:53 / 61
页数:9
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