Control of Listeria monocytogenes virulence by 5′-untransiated RNA

被引：25

作者：

Loh, Edmund ^{[1
]}

Gripenland, Jonas ^{[1
]}

Johansson, Jorgen ^{[1
]}

机构：

[1] Umea Univ, Dept Mol Biol, S-90187 Umea, Sweden

来源：

TRENDS IN MICROBIOLOGY | 2006年 / 14卷 / 07期

关键词：

D O I：

10.1016/j.tim.2006.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Gram-positive bacterium Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. Expression of five of these factors has previously been shown to be subjected to post-transcriptional regulation as a result of their long W-untranslated region (5-UTR). We have investigated the presence of 5'-UTRs among the other known virulence genes and genes that encode putatively virulence-associated surface proteins. Our results strongly suggest that L. monocytogenes controls many of its virulence genes by a mechanism that involves the 5-UTR. These findings further emphasize the importance of post-transcriptional control for L. monocytogenes virulence.

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收藏

页码：294 / 298

页数：5

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