Phenotypical and morphological changes in the thymic microenvironment from ageing mice

被引：50

作者：

Aw, Danielle ^{[1
,2
]}

Taylor-Brown, Frances ^{[1
,2
]}

Cooper, Kate ^{[1
,2
]}

Palmer, Donald B. ^{[1
,2
]}

机构：

[1] Univ London Royal Vet Coll, Dept Vet Basic Sci Infect & Immun, London NW1 0TU, England

[2] Univ London Royal Vet Coll, Genes & Dev Grp, London NW1 0TU, England

来源：

BIOGERONTOLOGY | 2009年 / 10卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Thymic involution; Thymic epithelial cells; Cytokeratin; EPITHELIAL-CELLS; LYMPHOHEMATOPOIETIC PROGENITORS; MURINE THYMUS; EXPRESSION; DIFFERENTIATION; INVOLUTION; REGENERATION; THYMOCYTE; MOUSE; IMMUNOSENESCENCE;

D O I：

10.1007/s10522-008-9182-2

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

The thymus is crucial for T-cell output and the age-associated involution of this organ, is thought to have a major impact in the decline in immunity that is seen in later life. The mechanism that underlines thymic involution is not known, however, we have evidence to suggest that this is may be due to changes in the thymic microenvironment. To further test this hypothesis, we quantified the in situ changes to markers that identify cortical and medullary thymic epithelial cells. This analysis revealed an age-dependent decline in cortical and medullary markers together with an increase in Notch and Delta expression, in older mice, as judged by immunohistochemistry. This was accompanied by alterations of the archetypal staining patterns and three dimensional analysis revealed changes in the morphology of the thymic microenvironment. These studies suggest that there are age-associated alterations in the thymic microenvironment, which may therefore play a role in thymic involution.

引用

页码：311 / 322

页数：12

共 49 条

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