Accelerated and improved osteointegration of implants biocoated with bone morphogenetic protein 2 (BMP-2)

被引：42

作者：

Jennissen, HP ^{[1
]}

机构：

[1] Univ Essen Gesamthsch, Inst Physiol Chem, D-45122 Essen, Germany

来源：

REPARATIVE MEDICINE: GROWING TISSUES AND ORGANS | 2002年 / 961卷

关键词：

osteointegration; bone implant healing; bone morphogenetic protein 2 (BMP-2); biocoating of implantable metals;

D O I：

10.1111/j.1749-6632.2002.tb03067.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A concept and methodology are presented for the direct biocoating of implantable metals like titanium and stainless steel with bone morphogenetic protein 2 (BMP-2) for future applications as cementless bone or dental prostheses. Such bioactive surfaces can influence cells and tissues by chemotactic as well as juxtacrine mechanisms. Reference is made to first experiments in sheep and rabbits in which BMP-2 coatings impressively increased the osteoinductive potential of titanium implants.

引用

页码：139 / 142

页数：4

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