Interleukin-8 - An early marker for bacterial infection

被引：14

作者：

Hirao, Y ^{[1
]}

Kanda, T ^{[1
]}

Aso, Y ^{[1
]}

Mitsuhashi, M ^{[1
]}

Kobayashi, I ^{[1
]}

机构：

[1] Yamano Coll Anesthet, Hachioji, Tokyo, Japan

来源：

LABORATORY MEDICINE | 2000年 / 31卷 / 01期

关键词：

D O I：

10.1309/GJ98-JAH8-VQ57-D6N0

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The cytokine network is activated in the pathogenetic mechanisms of septic diseases, We measured serum concentrations of interleukin-8 (IL-8) in 152 patients with septic syndrome and 25 control subjects, IL-8 concentration in patients with septic syndrome was significantly (P<.05) higher than in controls. Se-rum IL-8 concentration was assayed prospectively in 6 patients undergoing chemotherapy for leukemia. Increased IL-8 concentration preceded onset of fever and elevation of C-reactive protein by 1 day, Human peripheral whole blood cells were stimulated with phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide (LPS), or lipoteichoic acid, IL-8 mRNA expression was detected 10 minutes after PMA or LPS exposure, and IL-8 was secreted into culture media 3 hours after exposure, These data suggest that IL-8 is a useful early indicator of bacterial infection.

引用

页码：39 / 44

页数：6

共 17 条

[1]

Aso Y, 1998, CLIN CHEM, V44, P1782

[2] NEUTROPHIL-ACTIVATING PEPTIDE-1 INTERLEUKIN-8, A NOVEL CYTOKINE THAT ACTIVATES NEUTROPHILS [J].