Nuclear chaperones

We discuss nuclear chaperones that bind correctly folded protein subunits and mediate molecular interactions, particularly between proteins and nucleic acids. The clarge of these chaperones helps to prevent non-specific electrostatic interactions between the components. Thus, an ordered assembly of macromolecular complexes is mediated most notably in the formation and maintenance of chromatin, though similar principles ere likely to apply in ribonucleoprotein assembly. Here, we discuss roles for nuclear chaperones ones in mediating nucleosome assembly and remodelling during DNA replication and transcription, and upon fertilisation.