Role of mitochondrial dysfunction in Alzheimer's disease

被引：286

作者：

Castellani, R

Hirai, K

Aliev, G

Drew, KL

Nunomura, A

Takeda, A

Cash, AD

Obrenovich, ME

Perry, G

Smith, MA

机构：

[1] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA

[2] Takeda Chem Ind Ltd, Pharmaceut Res Labs 1, Div Pharmaceut Res, Osaka, Japan

[3] Case Western Reserve Univ, Dept Anat, Cleveland, OH 44106 USA

[4] Univ Alaska, Inst Arctic Biol, Fairbanks, AK 99701 USA

[5] Asahikawa Med Coll, Dept Psychiat & Neurol, Asahikawa, Hokkaido 078, Japan

[6] Tohoku Univ, Dept Neurol, Sch Med, Sendai, Miyagi 980, Japan

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2002年 / 70卷 / 03期

关键词：

Alzheimer's disease; mitochondria; oxidative stress;

D O I：

10.1002/jnr.10389

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease. (C) 2002 Wiley-Liss, Inc.

引用

页码：357 / 360

页数：4

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