A renaissance for SRC

被引：945

作者：

Yeatman, TJ ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrc1366

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The c-SRC non-receptor tyrosine kinase is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. These observations have led to the recent targeting of c-SRC for the development of anticancer therapeutics, which show promise as a new avenue for cancer treatment. Despite this, however, the precise functions of c-SRC in cancer remain unclear. In addition to increasing cell proliferation, a key role of c-SRC in cancer seems to be to promote invasion and motility, functions that might contribute to tumour progression.

引用

页码：470 / 480

页数：11

共 116 条

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