A renaissance for SRC

被引：945

作者：

Yeatman, TJ ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrc1366

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The c-SRC non-receptor tyrosine kinase is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. These observations have led to the recent targeting of c-SRC for the development of anticancer therapeutics, which show promise as a new avenue for cancer treatment. Despite this, however, the precise functions of c-SRC in cancer remain unclear. In addition to increasing cell proliferation, a key role of c-SRC in cancer seems to be to promote invasion and motility, functions that might contribute to tumour progression.

引用

页码：470 / 480

页数：11

共 116 条

[11] Focal adhesions, contractility, and signaling [J].

Burridge, K ;

ChrzanowskaWodnicka, M .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :463-518

[12]

Cam WR, 2001, CANCER, V92, P61, DOI 10.1002/1097-0142(20010701)92:1<61::AID-CNCR1292>3.0.CO

[13]

2-D

[14] A novel role for FAK as a protease-targeting adaptor protein: Regulation by p42 ERK and Src [J].

Carragher, NO ;

Westhoff, MA ;

Fincham, VJ ;

Schaller, MD ;

Frame, MC .

CURRENT BIOLOGY, 2003, 13 (16) :1442-1450

[15] Calpain: a role in cell transformation and migration [J].

Carragher, NO ;

Frame, MC .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2002, 34 (12) :1539-1543

[16] C-SRC REGULATES THE SIMULTANEOUS REARRANGEMENT OF ACTIN CYTOSKELETON, P190RHOGAP, AND P120RASGAP FOLLOWING EPIDERMAL GROWTH-FACTOR STIMULATION [J].

CHANG, JH ;

GILL, S ;

SETTLEMAN, J ;

PARSONS, SJ .

JOURNAL OF CELL BIOLOGY, 1995, 130 (02) :355-368

[17] Coupling assembly of the E-cadherin/β-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells [J].

Chen, YT ;

Stewart, DB ;

Nelson, WJ .

JOURNAL OF CELL BIOLOGY, 1999, 144 (04) :687-699

[18] PROTEIN-KINASE ACTIVITY ASSOCIATED WITH AVIAN-SARCOMA VIRUS SRC GENE PRODUCT [J].

COLLETT, MS ;

ERIKSON, RL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (04) :2021-2024

[19] TYR527 IS PHOSPHORYLATED IN PP60C-SRC - IMPLICATIONS FOR REGULATION [J].

COOPER, JA ;

GOULD, KL ;

CARTWRIGHT, CA ;

HUNTER, T .

SCIENCE, 1986, 231 (4744) :1431-1434

[20] ACTIVATION OF SRC FAMILY KINASES BY COLONY STIMULATING FACTOR-I, AND THEIR ASSOCIATION WITH ITS RECEPTOR [J].

COURTNEIDGE, SA ;

DHAND, R ;

PILAT, D ;

TWAMLEY, GM ;

WATERFIELD, MD ;

ROUSSEL, MF .

EMBO JOURNAL, 1993, 12 (03) :943-950

← 1 2 3 4 5 6 7 8 9 10 →