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A renaissance for SRC

被引：945
作者：
Yeatman, TJ [1 ]
机构：
[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
来源：
NATURE REVIEWS CANCER | 2004年 / 4卷 / 06期
关键词：
D O I：
10.1038/nrc1366
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The c-SRC non-receptor tyrosine kinase is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. These observations have led to the recent targeting of c-SRC for the development of anticancer therapeutics, which show promise as a new avenue for cancer treatment. Despite this, however, the precise functions of c-SRC in cancer remain unclear. In addition to increasing cell proliferation, a key role of c-SRC in cancer seems to be to promote invasion and motility, functions that might contribute to tumour progression.
引用
收藏
页码：470 / 480
页数：11
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