A synthetic DNA walker for molecular transport

被引：613

作者：

Shin, JS

Pierce, NA ^{[1
]}

机构：

[1] CALTECH, Dept Bioengn, Pasadena, CA 91125 USA

[2] CALTECH, Dept Computat & Appl Math, Pasadena, CA 91125 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 35期

关键词：

D O I：

10.1021/ja047543j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching. Copyright © 2003 American Chemical Society.

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页码：10834 / 10835

页数：2

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