Role of β1- and β2-adrenoceptor polymorphisms in heart failure:: a case-control study

被引:46
作者
Covolo, L
Gelatti, U
Metra, M
Nodari, S
Piccichè, A
Pezzali, N
Zani, C
Alberti, A
Donato, F
Nardi, G
Cas, LD
机构
[1] Univ Brescia, Spedali Civili, Cattedra Cardiol, I-25123 Brescia, Italy
[2] Univ Brescia, Cattedra Igiene, I-25123 Brescia, Italy
关键词
heart failure; beta; 1-adrenoceptor; 2-adrenoceptor; genetic polymorphism; case-control study;
D O I
10.1016/j.ehj.2004.06.015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background We hypothesised that the polymorphisms of the genes encoding for beta1-and the beta2-adrenoceptors may have a role in the pathogenesis of heart failure (HF). We therefore compared the polymorphisms of the beta1-adrenoceptor gene (Arg389Gly), the beta2-adrenoceptor gene (Arg16Gly, Gln27Glu) and their combinations in patients with HF and normal subjects living in the same area. Methods and results A total of 256 cases with HF (left ventricular ejection fraction less than or equal to 40%) and 230 normal subjects were enrolled. The beta1- and beta2-adrenoceptor gene polymorphisms were assessed by PCR, followed by restriction enzyme digestion. No differences were observed in the distribution of any of the three genotypes studied in patients with HF and normal subjects. An analysis of the genotype combinations showed a non-significant increase in the risk of HF associated with the Arg389Gly16Gln27 (odds ratio = 1.4; 95%CI 0.5-3.6) and Arg389Gly16 Glu27 (odds ratio = 1.2; 95%CI, 0.5-2.8) homozygous allele combinations. Conclusion None of the three most common polymorphisms of beta-adrenoreceptors are associated with an increased risk of HF. (C) 2004 Published by Elsevier Ltd on behalf of The European Society of Cardiology.
引用
收藏
页码:1534 / 1541
页数:8
相关论文
共 39 条
[1]  
Adams Kirkwood F. Jr., 2001, American Journal of Medicine, V110, p6S
[2]   Polymorphism in the β1-adrenergic receptor gene and hypertension [J].
Bengtsson, K ;
Melander, O ;
Orho-Melander, M ;
Lindblad, U ;
Ranstam, J ;
Råstam, L ;
Groop, L .
CIRCULATION, 2001, 104 (02) :187-190
[3]   beta-Adrenergic signal transduction in the failing and hypertrophied myocardium [J].
Bohm, M ;
Flesch, M ;
Schnabel, P .
JOURNAL OF MOLECULAR MEDICINE-JMM, 1997, 75 (11-12) :842-848
[4]   A novel polymorphism in the gene coding for the beta1-adrenergic receptor associated with survival in patients with heart failure [J].
Börjesson, M ;
Magnusson, Y ;
Hjalmarson, Å ;
Andersson, B .
EUROPEAN HEART JOURNAL, 2000, 21 (22) :1853-1858
[5]   Positional genomic analysis identifies the β2-adrenergic receptor gene as a susceptibility locus for human hypertension [J].
Bray, MS ;
Krushkal, J ;
Li, L ;
Ferrell, R ;
Kardia, S ;
Sing, CF ;
Turner, ST ;
Boerwinkle, E .
CIRCULATION, 2000, 101 (25) :2877-2882
[6]   β-adrenergic receptor blockade in chronic heart failure [J].
Bristow, MR .
CIRCULATION, 2000, 101 (05) :558-569
[7]   In-vivo studies do not support a major functional role for the Gly389Arg β1-adrenoceptor polymorphism in humans [J].
Büscher, R ;
Belger, H ;
Eilmes, KJ ;
Tellkamp, R ;
Radke, J ;
Dhein, S ;
Hoyer, PF ;
Michel, MC ;
Insel, PA ;
Brodde, OE .
PHARMACOGENETICS, 2001, 11 (03) :199-205
[8]   Prevention and management of chronic heart failure in patients at risk [J].
Cas, LD ;
Metra, M ;
Nodari, S ;
Cas, AD ;
Gheorghiade, M .
AMERICAN JOURNAL OF CARDIOLOGY, 2003, 91 (09) :10F-17F
[9]   β2-adrenergic receptor gene cardiovascular polymorphism, age, and phenotypes [J].
Castellano, M ;
Rossi, F ;
Giacchè, M ;
Perani, C ;
Rivadossi, F ;
Muiesan, ML ;
Salvetti, M ;
Beschi, M ;
Rizzoni, D ;
Agabiti-Rosei, E .
HYPERTENSION, 2003, 41 (02) :361-367
[10]   β2-adrenoceptor polymorphism determines vascular reactivity in humans [J].
Cockcroft, JR ;
Gazis, AG ;
Cross, DJ ;
Wheatley, A ;
Dewar, J ;
Hall, IP ;
Noon, JP .
HYPERTENSION, 2000, 36 (03) :371-375