Nanoparticles in cellular drug delivery

被引：753

作者：

Faraji, Amir H.

Wipf, Peter ^{[1
]}

机构：

[1] Univ Pittsburgh, Ctr Chem Methodol & Lib Dev, Pittsburgh, PA 15260 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Nanomaterials; Nanoparticles; Drug delivery; Targeted therapeutics; WALLED-CARBON-NANOTUBES; PEGYLATED POLYCYANOACRYLATE NANOPARTICLES; RESPONSIVE CONTROLLED-RELEASE; PARTICULATE AIR-POLLUTION; LAYERED DOUBLE HYDROXIDES; LOW-DENSITY-LIPOPROTEIN; CALCIUM-PHOSPHATE; IN-VIVO; OXIDATIVE STRESS; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.bmc.2009.02.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This review highlights the properties of nanoparticles used in targeted drug delivery, including delivery to cells as well as organelle targets, some of the known pharmacokinetic properties of nanoparticles, and their typical modi. cations to allow for therapeutic delivery. Nanoparticles exploit biological pathways to achieve payload delivery to cellular and intracellular targets, including transport past the blood-brain barrier. As illustrative examples of their utility, the evaluation of targeted nanoparticles in the treatment of cancers and diseases of the central nervous system, such as glioblastoma multiforme, neurovascular disorders, and neurodegenerative diseases, is discussed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2950 / 2962

页数：13

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