Sensitivity and allergy to latex in atopic and non-atopic children

被引:61
作者
Liebke, C [1 ]
Niggemann, B [1 ]
Wahn, U [1 ]
机构
[1] HUMBOLDT UNIV BERLIN,VIRCHOW CLIN,CHILDRENS HOSP,DIV PEDIAT PNEUMOL & IMMUNOL,D-13353 BERLIN,GERMANY
关键词
allergy; atopic; children; latex; non-atopic; sensitivity;
D O I
10.1111/j.1399-3038.1996.tb00115.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
To study the sensitivity and allergy to latex in children, we investigated sera of 306 atopic and 303 non-atopic children (median age 4.5 years) for specific IgE to latex. In patients with specific IgE to latex, a questionnaire was sent to families and provocation tests were carried out. 60/306 atopic children (20.8 %) and 1/303 non-atopic children (0.3 %) showed specific IgE to latex in serum. The proportion of atopic, latex-sensitized and provocation positive children was 12/48 (25 %). Specific IgE to latex was significantly higher (p < 0.03) in symptomatic compared to non-symptomatic patients. Specificity of a positive history was 92 %, sensitivity 50 %. Atopic dermatitis tended to be more prevalent among the 12 provocation positive atopic children (75 %) compared to 36 provocation negative children (58 %). There was a tendency that children of the symptomatic group underwent surgical interventions more frequently compared to non-symptomatic children. In conclusion, latex sensitization and latex allergy seem to have occured more often in atopic children than previously known. Risk factors for the development of a sensitization to latex are atopy and the clinical diagnosis of atopic dermatitis; risk factors for a clinically manifest allergy to latex are an elevated specific IgE to latex, a positive history upon contact to material containing latex and probably frequent operations. Provocation tests should be performed to plan avoidance measures in latex-allergic children especially before surgical interventions.
引用
收藏
页码:103 / 107
页数:5
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