A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra

被引：62

作者：

Hsieh, PW

Chang, FR

Lee, KH

Hwang, TL

Chang, SM

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[3] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan 333, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 07期

关键词：

D O I：

10.1021/np0400196

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A novel anti-HIV alkaloid, drymaritin (1), and a new C-glycoside flavonoid, diandraflavone (2), along with eight known compounds, torosaflavone A, isovitexin, spinasterol beta-D-glycoside, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, cis-p-coumarate, methyl 5-hydroxy-4-oxopentanoate, and glycerol-alpha-lignocerate, were isolated from Drymaria diandra. Drymaritin (1) exhibited anti-HIV effects in H9 lymphocytes with an EC50 value of 0.699 mug/mL and a TI of 20.6. Compound 2 showed significantly selective inhibition on superoxide anion generation from human neutrophils stimulated by fMLP/CB with an IC50 value of 10.0 mug/mL.

引用

页码：1175 / 1177

页数：3

共 21 条

[1]

ISOTUBOFLAVINE AND NORISOTUBOFLAVINE . 2 NEW ALKALOIDS ISOLATED FROM PLEIOCARPA MUTICA BENTH [J].