The host cytosol: front-line or home front?

被引:33
作者
O'Riordan, M
Portnoy, DA
机构
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA
关键词
D O I
10.1016/S0966-842X(02)02401-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Intracellular pathogens replicate in modified vacuolar compartments or in the cytosol of host cells. Many pathogenic bacterial species have evolved to modify the host vacuolar environment, but little is known about the mammalian cytosol as a medium for bacterial growth. Recent studies indicate that the cytosol is restrictive for the growth of bacteria other than cytosolic pathogens in contrast to earlier research that provided evidence that any bacteria with access to the cytosol can replicate there. Comparison of these studies suggests that the cytosolic contents of various host cell types can be differentially permissive for bacterial growth, and that both host and bacterial factors are important in determining the ability of particular bacteria to replicate in the cytosol.
引用
收藏
页码:361 / 364
页数:4
相关论文
共 49 条
  • [1] SALMONELLA-TYPHIMURIUM ACTIVATES VIRULENCE GENE-TRANSCRIPTION WITHIN ACIDIFIED MACROPHAGE PHAGOSOMES
    ARANDA, CMA
    SWANSON, JA
    LOOMIS, WP
    MILLER, SI
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10079 - 10083
  • [2] PROLINE INCORPORATION INTO PROTEIN BY RICKETTSIA-PROWAZEKII DURING GROWTH IN CHINESE-HAMSTER OVARY (CHO-K1) CELLS
    AUSTIN, FE
    WINKLER, HH
    [J]. INFECTION AND IMMUNITY, 1988, 56 (12) : 3167 - 3172
  • [3] RICKETTSIA-PROWAZEKII REQUIRES HOST-CELL SERINE AND GLYCINE FOR GROWTH
    AUSTIN, FE
    TURCO, J
    WINKLER, HH
    [J]. INFECTION AND IMMUNITY, 1987, 55 (01) : 240 - 244
  • [4] Barzu S, 1997, INFECT IMMUN, V65, P1599
  • [5] TRYPTOPHAN DEPLETION AS A MECHANISM OF GAMMA-INTERFERON-MEDIATED CHLAMYDIAL PERSISTENCE
    BEATTY, WL
    BELANGER, TA
    DESAI, AA
    MORRISON, RP
    BYRNE, GI
    [J]. INFECTION AND IMMUNITY, 1994, 62 (09) : 3705 - 3711
  • [6] ALTERED INTRACELLULAR TARGETING PROPERTIES ASSOCIATED WITH MUTATIONS IN THE LEGIONELLA-PNEUMOPHILA DOTA GENE
    BERGER, KH
    MERRIAM, JJ
    ISBERG, RR
    [J]. MOLECULAR MICROBIOLOGY, 1994, 14 (04) : 809 - 822
  • [7] 2 DISTINCT DEFECTS IN INTRACELLULAR GROWTH COMPLEMENTED BY A SINGLE GENETIC-LOCUS IN LEGIONELLA-PNEUMOPHILA
    BERGER, KH
    ISBERG, RR
    [J]. MOLECULAR MICROBIOLOGY, 1993, 7 (01) : 7 - 19
  • [8] Salmonella maintains the integrity of its intracellular vacuole through the action of SifA
    Beuzón, CR
    Méresse, S
    Unsworth, KE
    Ruíz-Albert, J
    Garvis, S
    Waterman, SR
    Ryder, TA
    Boucrot, E
    Holden, DW
    [J]. EMBO JOURNAL, 2000, 19 (13) : 3235 - 3249
  • [9] BACILLUS-SUBTILIS EXPRESSING A HEMOLYSIN GENE FROM LISTERIA-MONOCYTOGENES CAN GROW IN MAMMALIAN-CELLS
    BIELECKI, J
    YOUNGMAN, P
    CONNELLY, P
    PORTNOY, DA
    [J]. NATURE, 1990, 345 (6271) : 175 - 176
  • [10] BOUWER HGA, 1994, J IMMUNOL, V152, P5352